*All times are shown in EDT
7:30 am Online Networking Coffee
7:50 am Opening Remarks from Chairperson
Recent Advancements in Targeted Therapy and Immunotherapy in the Treatment of Advanced NSCLC
8:00 am Then and Now: NSCLC Therapies
Synopsis
- This session will summarize the recent advances in advanced/ metastatic NSCLC therapeutics with a specific focus on emerging drug candidates (in early-phase I/II clinical trials) and highly anticipated combination studies.
8:30 am Panel Discussion: Addressing the Shortcomings of Developing NSCLC-Targeted Therapies
Synopsis
- Patient population response differences and how to overcome these
- What design elements are most optimal to achieve clinical benefit?
- The push to early disease: what will this entail?
- How can the mechanism of action be predicted for each patient and thus inform dosing strategies?
Generations of Progress in Targeting EGFR Through TKIs
9:00 am The Osimertinib Story – Innovating & Learning from Every Chapter to Beat T790M Resistance & Advance into Early EGFRm Disease
Synopsis
- Chapter 1 – Delivering one of the fastest-ever development programmes: Tackling T790M driven resistance through novel chemistry; creating innovative study designs focused on patient selection, selecting the right dose, driving seamless worldwide trials and registration strategies; and acting fast on what we learned from the data to rapidly expand into first-line and adjuvant settings.
- Chapter 2 – Today’s focus: Building on yesterday’s foundations to extend osimertinib into early disease to improve patient outcomes.
- Chapter 3 – Looking ahead, the future focus takes osimertinib a step beyond into more lines of treatment: going further into earlier disease settings; addressing locally advanced, unresectable disease; and unlocking potential for combination opportunities that could be the key to targeting resistance mechanisms
9:30 am Addressing EGFR Mutation-Driven Resistance Using Next-Generation EGFR Inhibitors
Synopsis
• EGFR resistance mutations limit the clinical impact of approved tyrosine kinase inhibitors in EGFR-mutated NSCLC
• Discovery and characterization of EGFR wild-type sparing inhibitors with potent activity against the two major EGFR resistance mutations T790M and C797S
• Next generation EGFR inhibitors prevent and tackle resistance mutations arising upon treatment with approved EGFR inhibitors
10:00 am Speaker Q&A
10:10 am Virtual speed networking break
Synopsis
Grab a quick cup of tea or coffee from the comfort of your own home office and jump straight into the speed networking session. This is your opportunity to connect with new contacts from active companies in the field and exchange digital business cards. Network and form lasting connections through this exclusive virtual speed networking!
Targeting Mutation and Overexpression in EGFR
10:30 am Efficacy and Safety of Mobocertinib in NSCLC Patients with EGFR Exon 20 Insertions
Synopsis
- Overview of EGFR exon20 insertions in NSCLC and how they differ from common sensitizing EGFR mutations
- Current challenges associated with targeting these alterations and theneed for effective therapies
- Preclinical and clinical profile of Mobocertinib
11:00 am Discovery and Early Clinical Development of CLN-081 (TAS6417) in NSCLC with EGFR Exon 20 Insertion Mutations
Synopsis
- Challenges in the discovery of an Ex20 targeted therapy
- Preclinical characterization of CLN-081 in models of Ex20 NSCLC
- Safety and early signs of efficacy in patients with Ex20 NSCLC
11:30 am Speaker Q&A
11:40 am Targeting EGFR through ADCs:
Synopsis
- Lessons learned
- Future perspectives
12:40 pm BDTX-189: A MasterKey Inhibitor of EGFR and HER2 Exon 20 Insertion Mutations and Allosteric HER2 Mutations
Synopsis
• The role of Black Diamond’s proprietary MAP platform for the identification and validation of allosteric EGFR and HER2 oncogenic driver mutations, including Exon 20 insertion mutations
• Overview of the profile of BDTX-189, including a presentation of preclinical pharmacokinetic, safety, and anti-tumor activity data
• The ongoing MasterKey-01 trial, a Phase 1/2 clinical trial designed to evaluate BDTX-189 for the treatment of patients with solid tumors with a range of allosteric EGFR and HER2 mutations
1:10 pm Speaker Q&A
1:25 pm Online Networking Lunch
Targeting the MET Oncogene in NSCLC
2:05 pm Preclinical Evaluation of MCLA-129: A Bispecific Antibody Targeting c-MET and EGFR
Synopsis
- Functional screening antibody panel
- Inhibition of signaling
- Fc mediated MOA
2:35 pm Speaker Q&A
Targeting PI3K and Associated Pathways to Address Resistance
2:40 pm Targeting PI3K and Associated Pathways to Address Resistance
2:55 pm Speaker Q&A
3:15 pm Networking Break
Drugging the Undruggable KRAS Mutation in NSCLC
3:35 pm Mechanisms of Resistance to KRAS G12C Inhibitors
Synopsis
- Are there any genetic determinants for resistance to KRAS inhibitors?
- Can we identify biomarkers to predict the response to KRAS inhibitors?
- Is KRAS degradation a valuable strategy to overcome drug resistance?
4:05 pm Targeting KRAS Mutant Non Small Cell Lung Cancer with Adagrasib: Current Status and Future Questions
Synopsis
- History of targeting KRAS in the clinic and recent advancements to directly target KRAS G12C
- Clinical progress of KRAS G12C inhibitors (e.g. adagrasib) and treatment of patients with NSCLC
- Future questions and directions for targeting KRAS G12C, including biomarkers and combination strategies
4:35 pm Mechanisms of Resistance to KRAS G12C Inhibition
5:05 pm Unique Dual RAF/MEK Inhibitor VS-6766 for KRAS Mutant NSCLC
Synopsis
• Combination of VS-6766 with FAK inhibitor for KRAS G12V mt NSCLC – preclinical rationale
• Combination of VS-6766 with FAK inhibitor for KRAS G12V mt NSCLC – clinical data
• Combination of VS-6766 with a G12C inhibitor for KRAS G12C mt NSCLC
5:35 pm Speaker Q&A
5:40 pm Closing Remarks from the Chair
5:50 pm End of day
