*All times are shown in EDT

7:50 am Opening Remarks from Chairperson

  • Andreas Pircher Chair Translational Research Program, Department of Internal Medicine V, Hematology and Oncology, Medical University Innsbruck

Immunotherapy Strategy for NSCLC

8:00 am Independent Action, Collateral Sensitivity, & Directions For Future Progress For Immune Checkpoint Inhibitors in NSCLC

  • Emmett V. Schmidt Vice President, Clinical Research Lead, External Collaborations Oncology Early Development , Merck and Co


  • What is old is still true: current approved immune checkpoint inhibitor combinations depend on combinations of orthogonal cancer therapies according to principles of independent activity
  • The future is here: The emerging landscape of post-PD-1 treatment trials
  • What is old is still true: A reminder of collateral sensitivity as a historic combination principle

8:30 am Is Now the Critical Tipping Point for Progress with Immunotherapy in Resectable NSCLC? Where Are We Now and What’s to Come in 2021 and Beyond?

  • Tony Jarkowski Executive Director, Early Development Program Lead, Bristol Myers- Squibb


  • Review historical data along with current approaches for potentially resectable NSCLC
  • Discuss drug development in NSCLC and why progress in resectable NSCLC has lagged behind advanced stages of disease
  • Describe emerging data, science, and future opportunities for immunotherapy to improve outcomes within resectable NSCLC, including the neoadjuvant, adjuvant and peri-adjuvant settings

9:00 am A Soluble LAG-3 Protein (Eftilagimod Alpha) with an Anti-PD-1 Antibody (Pembrolizumab): Results of a Phase II Study in NSCLC


  • An MHC class II agonist (eftilagimod) used as an antigen presenting cell (APC) activator combined with an immune checkpoint inhibitor (ICI): a unique combination in immuno-oncology
  • Results in first and second (in PD-X refractory patients) lines non-small cell lung carcinoma (NSCLC)

9:30 am Could Neoantigen Immunotherapies Reverse Resistance to PD-1 Inhibitors & Progression in NSCLC?

9:50 am Reprogramming of the Lung Cancer Tumour Microenvironment with the AXL Inhibitor Bemcentinib.

  • Hani Gabra Chief Medical Officer & Head of Clinical Development , BerGenBio AS


• AXL expression is associated with poor prognosis in NSCLC and drives both aggressive cancer cell biology and innate immune suppression simultaneously
• Bemcentinib, a potent and specific, oral AXL kinase inhibitor reverses aggressive cancer cell behaviour and activates innate immunity leading to reengaged anti-tumour cytotoxic T cell responses
• Preliminary data from our clinical studies in second line relapsed/refractory NSCLC patients, demonstrate that bemcentinib mediates successful CP inhibition in AXL positive patients

10:20 am Morning Networking Coffee Break

Targeting Rare Mutations in NSCLC

10:50 am Targeting RAF Dimer Signaling in NSCLC Driven by BRAF Class II and III Mutations

  • Eric Murphy Co-Founder and Chief Scientific Officer , Kinnate Biopharma


  • Approved BRAF inhibitors such as vemurafenib, dabrafenib, and encorafenib are effective against cancers driven by V600 Class I mutations
  • BRAF Class II alterations (e.g. G469A or BRAF fusion) are RASindependent and RAF-dimer dependent and represent a molecular subtype in NSCLC with unmet need
  • BRAF Class III mutations represent a subtype with unmet need that are low kinase activity alterations that amplify upstream signaling from aberrant RTK (e.g. EGFR amplification) and/or RAS activation mechanisms
  • KIN-2787 is a clinical-stage pan-RAF inhibitor targeting dimer signaling in NSCLC patient populations while minimizing MAPK pathway paradoxical activation in normal wildtype signaling

11:20 am Targeting HER2 in NSCLC

  • Ralph Neumueller Senior Director - Cancer Research , Boehringer Ingelheim RCV GmbH & Co KG

11:50 am NRG1 Fusions: A Tumor-Agnostic Oncogenic Driver

  • Shawn Leland Founder & Chief Executive Officer , Elevation Oncology


  • Genomic alterations fall on a spectrum of oncogenic potential. “True” oncogenic driver alterations are optimal biomarkers for targeted therapy development in precision oncology
  • NRG1 fusions are emerging as “true” oncogenic driver alterations that can be found across solid tumor types and are enriched in certain NSCLC populations such as IMA
  • NRG1 fusions may be therapeutically actionable through inhibition of HER3 with mAbs such as seribantumab, currently being investigated in the Phase 2 tumor-agnostic CRESTONE trial

12:20 pm Screen Break Lunch

Optimizing Precision Oncology, Treatment Regimes and Administration to Improve Patient Outlook

12:50 pm Towards Furthering Liquid Biopsy Use in Clinical Studies

  • Donald Johann Associate Professor - Medicine & Bioinformatics , University of Arkansas for Medical Sciences/ ATD LLC


– Sample collection & best practices
– Towards analytical validity – accuracy & reproducibility
– Approaches towards data harmonization

1:20 pm EGFR Exon 20 Insertions : A Complex Family of Mutations in NSCLC


  • Current testing methodologies to identify EGFR exon insertion
  • Companion Diagnostic planning to improve identification of patients with EGFR exon 20 insertion
  • Impact of EGFR exon 20 insertion variants on mobocertinib response

1:50 pm Utility of Blood-Based Molecular Diagnostic Testing Across the Lung Cancer Continuum of Care


• Understand how our blood-based diagnostic tests support clinical decision-making for lung cancer diagnosis, treatment guidance, and longitudinal monitoring.
• Learn about our ongoing clinical studies geared at answering important clinical questions across the lung cancer continuum of care.
• Learn about our unique diagnostic methods and services to support ongoing biopharmaceutical and academic translational research for lung cancer drug development.

2:20 pm Screen Break

3:00 pm BloodPAC Consortium: Accelerating Development, Approval & Accessibility

  • Lauren Leiman Executive Director , Blood Profiling Atlas in Cancer

3:30 pm Panel Discussion: Utilizing Precision Oncology for NSCLC Treatment

  • Donald Johann Associate Professor - Medicine & Bioinformatics , University of Arkansas for Medical Sciences/ ATD LLC
  • Sylvie Vincent Scientific Director , Takeda Oncology
  • Lauren Leiman Executive Director , Blood Profiling Atlas in Cancer
  • Partha M. Das Medical Director and US Medical Affairs Lead, Oncology Diagnostics and Biomarker Strategy , Amgen
  • Angel Rodriguez Oncology Medical Director, Natera

4:00 pm Panel Discussion: Predicting Future Directions for NSCLC Therapeutic Development and Treatment

  • Tony Jarkowski Executive Director, Early Development Program Lead, Bristol Myers- Squibb
  • Martha Neagu Associate Medical Director, AbbVie
  • Eric Murphy Co-Founder and Chief Scientific Officer , Kinnate Biopharma


  • How will future combinations, or novel therapeutic design (bispecifics etc), address acquired resistance to TKI treatments and improve patient outcomes?
  • How will new, fast and accurate diagnostic technologies enable appropriate patient selection for future clinical investigations and increase the clinical utility of new approved therapies?
  • What is on the horizon for targeted therapies for uncommon or previous undruggable mutations in NSCLC?
  • What are the next steps for immunotherapy in this space? What are the highly anticipated combination studies and emerging drug candidates on the horizon?
  • Is 2021 the year that checkpoint inhibitors break into the perioperative setting in NSCLC?

4:30 pm Meet The Investors & Ask Your Burning Questions


• Hear from three leading investment experts & gain their invaluable insights
• What are their views on future directions?
• What do they look for in investments in this space
• Your chance to strategize & generate financial support for your clinical pipeline

5:15 pm Closing Remarks from Chairperson

5:20 pm End Of Conference